Two Heart Disease Theories, Same Therapeutic Treatment (cardiotonics)

 

Article published and commented in Dr. Thomas Cowan's Newsletter December/2005

 

References:

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  2. Cardiac glycosides: From ancient history through Withering's foxglove to endogenous cardiac glycosides, Norn S, Kruse PR. Dan Medicinhist Arbog 2004;119-32

  3. History of the heart and the circulation, Willius F A and Dry, T J; W B Saunders Company, 1948

  4. Herrick JB. Clinical features of sudden obstruction of the coronary arteries. JAMA 1912;59:2015-2019. Willius, F.A. and Keyes, T.E.: Cardiac Classics. The C.V. Mosby Company, 1941; St. Louis, USA

  5. Burch GE and col., Ischemic cardiomyopathy, Am Heart J. 1972 Mar;83(3):340-50

  6. Drew Luten, The clinical use of digitalis, Charles C Thomas, 1936

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  12. A study on the hemodynamic effect of cedilanid in the treatment of acute myocardial infarction, Qiao DR, Zhonghua Xin Xue Guan Bing Za Zhi. 1993 Apr;21(2):83-4, 122 http://www.tinyurl.com/a38uj

  13. Strophanthin, Bruno Kisch . Brooklin Medical Press, New York City, N. Y., 1944

  14. Peter Schmidsberger, Skandal Herzinfarkt. Die Hintergründe einer Epidemie und der Strophantin-Streit, 1975. http://www.melhorn.de/Strophskandal/SkandalHerzinfarkt.pdf

  15. Rolf-Jürgen Petry - Strophanthin: der mögliche Sieg über den Herzinfarkt, Verlag Florilegium, 2003. Summary in English with references at http://ouabain.twoday.net

  16. Quintiliano H. de Mesquita: Memorial at http://www.infarctcombat.org/qhm/homepage.html and Short biography at http://en.wikipedia.org/wiki/Quintiliano_H._de_Mesquita

  17. Myogenic Theory of Myocardial Infarction, Quintiliano H. de Mesquita, 1979 – Book and articles in English at http://www.infarctcombat.org/MyogenicTheory.html

  18. Ernst Edens Traditionsprize awarded to Quintiliano H. de Mesquita in 1975 by Internationale Gesselschaft für Infarktbekaempfung. Photo at http://www.infarctcombat.org/Traditionpreis/photo.html

  19. So bekämpft ein Brasilianer den herzinfarct, Bunte Magazine, Offenburg - Germany, 10/04/1980 http://www.infarctcombat.org/Bunte/photo.html

  20. Cardiotônico: Insuperável na Preservação da Estabilidade Miocárdica como Preventivo das Síndromes Coronárias Agudas e Responsável pela Prolongada Sobrevida -- Casuística de 28 anos (1972-2000), Mesquita, QHde e Baptista, CAS.  Ars Cvrandi, Volume 35 - nº 3 - maio de 2002.  Republished at Internet, 2005 http://www.infarctcombat.org/28anos/digitalicos.html with a summary in English at http://www.infarctcombat.org/heartnews-16.html

  21. Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM, Association of serum digoxin concentration and outcomes in patients with heart failure, JAMA. 2003;289:871-878 http://tinyurl.com/c7os3

  22. Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis, Adams KF Jr, Patterson JH, Gattis WA, O'Connor CM, Lee CR, Schwartz TA, Gheorghiade M., J Am Coll Cardiol. 2005 Aug 2;46(3):497-504 http://tinyurl.com/8ppnp

  23. Digoxin may reduce the mortality rates in patients with congestive heart failure, Wang L, Song S., Med Hypotheses. 2005;64(1):124-6. http://tinyurl.com/dcfv3

  24. Leor J, Goldbourt U et al. Digoxin and increased mortality among patients recovering from acute myocardial infarction: importance of digoxin dose, Cardiovasc Drugs Ther 1995 Oct;9(5):723-9 http://tinyurl.com/ao6ld

  25. Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure, Krum H, Bigger JT Jr, et al. J Am Coll Cardiol 1995 Feb, 25(2):289-94 http://tinyurl.com/5jsde

  26. Digoxin reduces cardiac sympathetic activity in severe congestive heart failure. Newton GE, Tong JH, J Am Coll Cardiol. 1996 Jul;28(1):155-61

  27. Mechanism of inhibition of catecholamine release from adrenal medulla by diphenylhydantoin and by low concentration of ouabain (10 (-10) M). Gutman Y, Boonyaviroj P. Naunyn Schmiedebergs Arch Pharmacol 1977 Feb;296(3):293-6.

  28. Effects of increasing maintenance dose of digoxin on left ventricular function and neurohormones in patients with chronic heart failure treated with diuretics and angiotensin-converting enzyme inhibitors, Gheorghiade M, Hall Vb et al. Circulation 1995 Oct 1;92(7):1801-7 http://circ.ahajournals.org/cgi/content/full/92/7/1801

  29. The level of plasma neuroendocrine activity and the concentration of digoxin in the serum of patients with mild chronic heart failure, Jablecka A et al. Int J Clin Pharmacol Res 1998;18 (4):171-8 http://tinyurl.com/5wkmx

  30. Neurohumoral features of myocardial stunning due to sudden emotional stress, Wittstein IS et al. New Engl J Med 2005 Feb 10,  V352: 539-548

  31. Increased cardiac sympathetic nervous activity in patients with unstable coronary heart disease, McCance AJ, Thompson PA, Forfar JC. Eur Heart J 1993 Jun;14(6):751-7

  32. Sympathetic neural hyperactivity and its normalization following unstable angina and acute myocardial infarction, Graham LN, Smith PA et al. Clin Sci (Lond) 2004 Jun;106(6):605-11

  33. Plasma catecholamine concentrations in myocardial infarction and angina pectoris, Gazes PC, Richardson JA et al. Circulation 1959;19:657-661

  34. A possible role of noradrenaline in the development of myocardial infarction, Waldenstrom AP et al. Am Heart J. 1978;95:43-51

  35. Plasma catecholamines in acute myocardial infarction, Nadeau RA, de Champlain J,  Am Heart J. 1979;98:548-554

  36. O Estresse Mental no Desencadeamento do Infarto Agudo do Miocárdio (ICEM, 2005) at http://www.infarctcombat.org/polemica-37/icem.html

  37. Botanical Medicine Monographs and Sundry, American Journal of Pharmacy, V53;8, August 1881 http://www.swsbm.com/AJP/AJP_1881_No_8.pdf

  38. Endogenous Cardiotonic Hormones: A New Argument for the Myogenic Theory of Myocardial Infarction (ICP, 2004)  http://www.infarctcombat.org/heartnews-18.html

  39. Na/K-ATPase, endogenous digitalis like compounds and cancer development – a hypothesis, Weidemann H. Front Biosci 2005 Sep 1;10:2165-76 http://tinyurl.com/9tbbe

  40. Is digitalis a therapy for breast carcinoma? Stenkvist B, Oncol Rep. 1999 May-Jun;6(3):493-6  http://tinyurl.com/7b9m9

  41. Digitoxin in non-toxic concentrations, inhibits proliferation and induces cell death in prostate cell lines, Haux et al. Z-Onkol, 2000, 32 (1):11-16

  42. Digitoxin is a potential anticancer agent for several types of cancer, Haux J, Med Hypotheses 1999 Dec; 53(6):543-8 http://tinyurl.com/7b9m9

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