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Myogenic Theory
Mechanism*
CORONARY ATHEROSCLEROSIS
SLOW
CORONARY FLOW
↓
STABLE ANGINA PECTORIS – SILENT CORONARIOPATHY
1-
RELATIVE MYOCARDIAL ISCHEMIA
2-
RECIPROCAL CONTRACTILE LOSS
↓
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PHYSICAL AND PSYCHO-EMOTIONAL STRESSING FACTORS
↓ |
PHARMACOLOGICAL FACTORS –
NEGATIVE INOTROPIC AGENTS
↓ |
SEGMENTARY MYOCARDIAL DISEASE
↓
UNSTABLE ANGINA / INTERMEDIARY SYNDROME
INFARCTIONING
CLINICAL PICTURE
1-
REGIONAL MYOCARDIAL INSUFFICIENCY
2-
RECIPROCAL MYOCARDIAL ISCHEMIA
↓
PRIMARY MYOCARDIAL NECROSIS
(INFARCTION)
↓
CORONARY STASIS OR FRAGMENTATION AND
DISPLACEMENT OF ATHEROMATOUS PLAQUE BY EDEMA
↓
SECONDARY CORONARY THROMBOSIS
(NOT
OBLIGATORY)
*Myogenic Theory of myocardial infarction. Book, 1979
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