71 – O cardiotônico na sindrome intermediária coronária, Mesquita, QHde, Baptista, CAS, Mari, SM, Monteiro, JTC, Grossi, MCBM, Rev Bras Med (Cardiologia), 1983;2:317-23
Contribuição inédita à literatura mundial.
There were 185 intermediate coronary syndrome patients, 10 treated at home and the others hospitalized at the Coronary Care Unit of the Matarazzo Hospital, who were administered cardiotonics: Strophanthin (150 pts.); Digitalis (39 pts,); 5 patients were treated with Proscilaridine (4 pts.) and Digitalis (1 pt.) by oral route. These patients were divided into 3 groups according to the coronary antecedents: Group I: previous myocardial infarction, 43 patients: Group II stable angina pectoris, 49 patients: Group III: no antecedents, 93 patients.
Phisiopathologically, the intermediate coronary syndrome is interpreted as recurrent from a myogenic process evolving to a myocardial infarction, characterized by episodes of primary regional myocardial failure and secondary myocardial ischemia.
Electrocardiographically and enzimatically the intermediate coronary syndrome is characterized by inexpressive aspects, but favorably influenced by the cardiotonic.
A sampling of 22 patients pertaining to the above mentioned Groups was studied angiographically and ventriculographically.
Special emphasis was put on Groups II and III, with no myocardial infarction in there antecedents, because they seem to give strength to the myogenic theory of myocardial infarction, by means of the registers of patients with total obstruction of 1, 2 or 3 coronary arteries by chronic atherosclerosis without myocardial infarction, and also patients without any coronary angiographic lesions, or else with severe stenotic coronary lesions, but pervious and threatened with myocardial infarction.
During the hospitalization phase slight arrhythmic but transient disorders were registered in 38 patients (20,5%).
The immediate and successful results obtained with administration of cardiotonics were: cessation of the episodes of unstable angina pectoris, exceptionally only the incidence of myocardial infarction (0,5%, 1 patient out of 185 pts.), and no case of lethal exit.