Reversible Dysfunction in Acute Myocardial Infarction by Dobutamine Confirm the Myogenic Theory


 Quintiliano H. de Mesquita, M.D.


In the present article we discuss the surprisingly results achieved by Steven Smart et al (Am. Heart J., 1997; 133: 822-834 ) in acute myocardial infarction, showing through the use of Dobutamine echocardiography the reversible dysfunction of akinetic and hypokinetic segments. These findings, in our point of view are perfectly compatible with the Myogenic Theory for AMI and consequent and obligatory treatment with cardiotonics, as defended by us since 1972.

Dobutamine in the same manner of cardiotonics is a potent agonist of Beta 1 adrenergic receptors, improving the left ventricular contractile function in AMI due to its positive inotropic effect. The study realized by Steven Smart shows during the echocardiography detection, successive effects over the ventricular contractile dysfunction developed by the AMI and the reversible dysfunction with the use of Dobutamine.